Physiology of Neuronal Cell Signaling
PhD (1994-1998) Louisiana State University
Post-doctoral researcher (1998-1999) Louisiana State University
Post-doctoral researcher (1999-2003) Colorado State University
Assistant Professor, Special Track (2003-2004) Colorado State
Assistant Professor (2004) University at Buffalo,
Associate Professor (2011-present) University at Buffalo
Department of Biological Sciences
619 Cooke Hall
State University of New York at Buffalo
Buffalo, NY 14260
Phone: (716) 645-4947
My lab studies the
physiology of signal transduction pathways and the regulation of
these pathways in neuronal systems. We focus on peripheral
sensory systems, primarily the taste system. Chemical sensory
systems, which are comprised of olfaction and taste, play
important roles in feeding, territorial recognition and social
interactions. The taste sensory system is used to determine
whether potential food items will be ingested or rejected while
the olfactory system is used in a multitude of behaviors such as
kin recognition and mate selection. The taste system is extremely
heterogeneous and is made up of multiple cell types that depend
on multiple signaling pathways to detect stimuli. Some stimuli
interact with receptors that initiate second messenger cascades,
while others interact directly with ion channels to cause a
cellular response. As characterization of these cellular
mechanisms continues, we can begin understanding how the brain
gathers information about its surroundings. The long term goal of
the lab is to begin understanding how signaling mechanisms are
regulated within taste cells and how this regulation impacts the
generation of the stimulus signal to the brain. We use molecular
and physiological techniques, including patch clamp analysis and
calcium imaging to investigate how signaling mechanisms in taste
Characterization of calcium
buffering mechanisms in taste cells of mice
Characterization of the PLCb3 signaling pathway in taste cells
* Defining the role of WT1 in taste development and maintenance
- Gao, Y. , Toska, E. , Denmon, D., Roberts, S.G.E., and Medler, K.F. (2014) WT1 regulates the development of the posterior taste field. Development In press.
- Medler, K.F. (2014) Taste cells and calcium signaling. Invited chapter in “Calcium: Chemistry, Analysis, Function, and Effects” for Food and Nutritional Components in Focus. Editor: Professor Victor R Preedy. Published by Royal Society of Chemistry
- Maliphol, A.B., Garth, D.J. and Medler, K.F., (2013) Diet-induced obesity reduces the responsiveness of the peripheral taste system. PLoS ONE 8(11):e79403.
- Toska, E., Shandilya, J., Medler, K.F., Goodfellow, S.J., and Roberts, S.G.E. (2013) Prohibitin is required for transcriptional repression by the WT1-BASP1 complex. Oncogene 10.1038/onc.2013.447.
- Rebello, M.R., Maliphol, A.B., and Medler, K.F. (2013). Ryanodine receptors selectively interact with L type calcium channels in mouse taste cells. PLoS ONE 8(6):e68174
- Toska, E., Campbell, H.A., Shandilya, J., Goodfellow, S.J., Shore, P., Medler, K.F., and Roberts, S.G.E. (2012) Repression of transcription by WT1-BASP1 requires the myristoylation of BASP1 and the PIP2-dependent recruitment of Histone Deacetylase. Cell Reports 2(3):462-9.
- Goodfellow, S.J., Rebello, M.R., Toska, E., Zeef,L., Rudd, S., Medler, K.F., and Roberts, S.G.E. (2011) WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line. Biochemical Journal 435(1):113-25.
- Rebello, M. R., Aktas, A and Medler, K.F. (2011) Expression of calcium binding proteins in mouse taste receptor cells. J. Histo & Cyto. 59(5): 530-539.
- Medler, K.F. (2011) Multiple roles for TRPs in the taste system: Not your typical TRPs. Invited chapter in “The Transient receptor potential channels” for the Advances in Experimental Medicine and Biology 704:831-46. Editor: Dr. Md. Shahidul Islam. Published by Springer, Inc.
- Starostik, M.R, Rebello, M.R., Cotter, K.A. , Kulik, A. and Medler, K.F. (2010) Expression of GABAergic receptors in mouse taste receptor cells. PLoS ONE 5(10): e13639.
- Rebello, M. R. and Medler, K.F. (2010) Ryanodine receptors selectively contribute to taste evoked responses in mouse taste receptor cells. Eur. J. Neurosci. 32(11): 1825-1835.
- Medler, K.F. (2010) Calcium signaling in taste cells: Regulation Required. Invited referred review for Chemical Senses. 35(9):753-65
- Szebenyi, S.A., Laskowski, A.I., and Medler, K.F. (2010) Sodium/calcium exchangers selectively regulate calcium signaling in mouse taste receptor cells. J. Neurophys. 104: 529-538.
- Laskowski, A.I. and Medler, K.F.(2009) Sodium/calcium exchangers contribute to the regulation of cytosolic calcium levels in mouse taste cells. J. Physiol. 587(16): 4077-4089.selected for Faculty of 1000 Biology
Clapp, T.R., Medler, K.F., Damak, S., Margolskee R.F., and Kinnamon, S.C. (2006) Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25. BMC Biology 4(1):7 *highly accessed designation.