BIO 404/504
Spring, 2012
NSC 218
[ MWF 11:00-12:10 ]
Instructors
| Dr. Margaret
Hollingsworth 653 Hochstetter 645-2968 hollings@buffalo.edu office hours by appointment Dr. Michael Yu |
Dr. Ronald
Berezney 637 Cooke 645-4956 berezney@buffalo.edu Office hours: by appointment Dr.
Paul Gollnick (Course Coordinator) Dr. Laurie Read |
Exams: There will be 4 exams, each of which will be 1/4 of the final grade. The last exam will not be cumulative. Make-up exams will be given only with a valid medical excuse and will be oral or written at the instructor's option. If you have a medical reason for missing an exam, the instructor must be notified within 24 hours of missing the exam. If notification is not given, you will receive a grade of zero for that exam. The following is an approximate schedule of lectures. Exam dates will not change. Readings will consist of references to the literature.
If you wish to use a book for reference, we recommend Genes IX by Benjamin Lewin. However, this book is not required for the course.
GRADUATE STUDENTS WITHOUT ADEQUATE PREPARATION (AN UNDERGRADUATE COURSE IN GENETICS) SHOULD NOT TAKE THIS COURSE.
LECTURE # |
DATE | TOPIC | INSTRUCTOR |
1 |
Jan. 18 | Introduction/Overview of course | Gollnick |
2 |
Jan. 20 | Overview of Molecular Biology/Techniques | Gollnick |
| Dr. Berezney's Lecture Material | |||
3 |
Jan. 23 | DNA Replication | Berezney |
4 |
Jan. 25 | DNA Replication | Berezney |
5 |
Jan. 27 | DNA Replication | Berezney |
6 |
Jan. 30 | Telomeres/Telomerase | Hollingsworth |
7 |
Feb. 1 | Telomeres/Telomerase | Hollingsworth |
8 |
Feb. 3 | RNA Polymerase Structure/Function | Gollnick |
9 |
Feb. 6 | Transcription Initiation | Gollnick |
10 |
Feb. 8 | Transcription Elongation | Gollnick |
11 |
Feb. 10 | Transcription Termination | Gollnick |
12 |
Feb. 13 | EXAM 1 (Covers Jan. 18 - Feb. 10) | ---------------- |
13 |
Feb. 15 | Transcription by RNA Polymerase II-General factors | Hollingsworth |
14 |
Feb. 17 | Regulation of RNA polymerase II transcription | Hollingsworth |
15 |
Feb. 20 | Regulation of Transcription Repressors/Activators | Gollnick |
16 |
Feb. 22 | Regulation of Transcription Attenuation/Antiterm | Gollnick |
17 |
Feb. 24 | Regulation of Transcription Riboswitches | Gollnick |
18 |
Feb. 27 | Transcription in Pox viruses | Gollnick |
19 |
Feb. 29 | Transcription in Pox viruses | Gollnick |
20 |
Mar. 2 | Mechanisms of eukaryotic transcriptional activation | Yu |
21 |
Mar. 5 | Eukaryotic transcriptional activation (tentative) | Yu |
22 |
Mar. 7 | Eukaryotic transcriptional activation (tentative) |
Yu |
23 |
Mar. 9 | EXAM 2 (Covers Feb. 15 - Mar. 5) | ---------------- |
24 |
Mar. 19 | RNA processing: 5' and 3' End Formation | Hollingsworth |
25 |
Mar. 21 | RNA processing: Splicing I | Hollingsworth |
26 |
Mar. 23 | RNA processing: Splicing II | Hollingsworth |
27 |
Mar. 26 | RNA interference: siRNA | Hollingsworth |
28 |
Mar. 28 | RNA interference: microRNA and other small RNAs | Hollingsworth |
29 |
Mar. 30 | RNA Editing | Read |
30 |
Apr. 2 | Basic Principles of Epigenetics | Yu |
31 |
Apr. 4 | Epigenetics: Regulation of Organization & Gene Expression | Yu |
32 |
Apr. 6 | Epigenetics: Mechanisms | Yu |
33 |
April 9 | EXAM 3 (Covers Mar. 19 - Apr. 6) | ---------------- |
34 |
Apr. 11 | Translation: Ribsome Structure/Function | Gollnick |
35 |
Apr. 13 | Translational Regulation | Gollnick |
36 |
Apr. 16 | Translational Regulation | Gollnick |
37 |
Apr. 18 | Posttranscriptional regulation in eukaryotes | Hollingsworth |
38 |
Apr. 20 | Posttranscriptional regulation in eukaryotes |
Hollingsworth |
39 |
Apr. 23 | RNA surveillance (NMD) | Hollingsworth |
40 |
Apr. 25 | RNA surveillance (NRD) | Hollingsworth |
41 |
Apr. 27 | RNA surveillance (NGD) | Hollingsworth |
42 |
Apr. 30 | EXAM
4 (Covers April 11 to April 27) |
---------------- |