BIO 404/504
Spring, 2009
NSC 218 (MWF 11:00-12:10)
Instructors
| Dr. Margaret
Hollingsworth (Coordinator) 653 Hochstetter 645-2363 ext 196 hollings@buffalo.edu office hours by appointment Dr.
Jeremy Bruenn Dr. Kiong Ho Dr. Michael Yu |
Dr. Ronald
Berezney 637 Cooke 645-2363 ext 154 berezney@buffalo.edu Office hours: by appointment Dr.
Paul Gollnick Dr. Laurie Read |
Exams: There will be 4 exams, each of which will be 1/4 of the final grade. The last exam will not be cumulative. Make-up exams will be given only with a valid medical excuse and will be oral or written at the instructor's option. If you have a medical reason for missing an exam, the instructor must be notified within 24 hours of missing the exam. If notification is not given, you will receive a grade of zero for that exam. The following is an approximate schedule of lectures. Exam dates will not change. Readings will consist of references to the literature.
If you wish to use a book for reference, we recommend Genes IX by Benjamin Lewin. However, this book is not required for the course.
GRADUATE STUDENTS WITHOUT ADEQUATE PREPARATION (AN UNDERGRADUATE COURSE IN GENETICS) SHOULD NOT TAKE THIS COURSE.
| DATE | TOPIC | INSTRUCTOR |
| Jan. 12 | Introduction/Overview | Gollnick |
| Jan. 14 | Overview of Molecular Biology | Gollnick |
| Dr. Berezney's Lecture Material Page | ||
| Jan. 16 | DNA Replication | Berezney |
| Jan. 21 | DNA Replication | Berezney |
| Jan. 23 | DNA Replication | Berezney |
| Jan. 26 | Telomerase | Hollingsworth |
| Jan. 28 | Telomere structure | Hollingsworth |
| Jan. 30 | RNA Polymerase Structure/Function | Gollnick |
| Feb. 2 | Transcription Initiation | Gollnick |
| Feb. 4 | Transcription Elongation | Gollnick |
| Feb. 6 | Transcription Termination | Gollnick |
| Feb. 9 | EXAM 1 | ---------------- |
| Feb. 11 | Regulation of Transcription Repression/Activation | Gollnick |
| Feb. 13 | Regulation of Transcription Attenuation/Antitermination | Gollnick |
| Feb. 16 | Regulation of Transcription Riboswitches | Gollnick |
| Feb. 18 | Translation: Ribosome Structure/Function | Gollnick |
| Feb. 20 | Regulation of Translation | Gollnick |
| Feb. 23 | Regulation of Translation | Gollnick |
| Feb. 25 | Eukaryotic Transcription (Initiation) | Ho |
| Feb. 27 | Eukaryotic Transcription (Activation) | Ho |
| Mar. 2 | Eukaryotic Transcription (Elongation-Termination) | Ho |
| Mar. 4 | Editing (Powerpoint File) Lehmann Article |
Read |
| Mar. 6 | EXAM 2 | ---------------- |
| Mar. 16 | mRNA Processing (5’ and 3’ End formation) | Ho |
| Mar. 18 | mRNA Processing (Splicing) | Ho |
| Mar. 20 | mRNA Processing (Splicing) | Ho |
| Mar. 23 | RNA Interference | Ho |
| Mar. 25 | Eukaryotic post-transcriptional control | Hollingsworth |
| Mar. 27 | Eukaryotic post-transcriptional control | Hollingsworth |
| Mar. 30 | rRNA surveillance (NMD) | Hollingsworth |
| Apr. 1 | rRNA surveillance (NRD) | Hollingsworth |
| Apr. 3 | RNA surveillance (NGD) | Hollingsworth |
| April 6 | EXAM 3 | ---------------- |
| Apr. 8 | Epigenetics in Biology - DNA methylation | Yu |
| Apr. 10 | Epigentics - histone modification & histone code | Yu |
| Apr. 13 | Epigenetics & genetic syndromes | Yu |
| Apr. 15 | Transposable elements | Bruenn |
| Apr. 17 | Transposable elements |
Bruenn |
| Apr. 20 | Retroviruses | Bruenn |
| Apr. 22 | Retroviruses | Bruenn |
| Apr. 24 | Transgenic | Bruenn |
| April 27 | Transgenic | Bruenn |
The Final Exam will be held during Finals Week |