This course gives an overview of the cell biology, genetics, development, physiology, ecology, and pathology of a wide variety of prokaryotic and eukaryotic microbes. The course also includes information about the immune system and its interactions with microbes. LEC

Textbook: Brock Biology of Microorganisms (12th Edition) by Madigan, Martinko, Dunlap, and Clark (Pearson Benjamin Cummings publishers) ISBN# 0-13-232460-1

Prerequisites: BIO205 (Biochemistry)

Course Instructor: Dr. Stephen J. Free (email free@buffalo.edu)

Attendance: Since the exams will largely reflect material covered during the lectures, students should attend all of the lectures.

Exams: There will be 4 exams given during the semester and the final grade will be determined based on these examinations. The penalty for cheating on an examination will be an F grade for the course and a letter indicating the F grade was given for dishonesty will be placed in the students file.

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Lecture Schedule:

I. Overview of the Microbial World

1. Introduction to microbiology – Chpt 1
2. The microbial world – Chpt 2
3. Biochemical basis of life – Chpt 3
4. Bacterial and Archaea cell structure – Chpt 4
5. Nutrition and biochemistry – Chpt 5
6. Microbial growth – Chpt 6
7. Evolution and Systematics – Chpt 14
8. Bacteria – Chpt 15 and 16
9. Archaea – Chpt 17
10. Eukaryotic microbes – Chpt 18
11. Review session
12. Exam #1

II. Molecular Biology of Microbes

13. Essentials Molecular Biology for bacteria - Chpt 7
14. Essential Molecular Biology for Archaea and Eukaryoes – Chpt 8
15. Regulation of Gene Expression – Chpt 9
16. Viruses and Virology – Chpt 10
17. Virus Diversity - Chpt 19
18. Bacterial Genetics – Chpt 11
19. Genetic Engineering – Chpt 12
20. Microbial Genomics – Chpt 13
21. Metabolic Diversity – Chpt 20
22. Metabolic Diversity - Chpt 21
23. Review session
24. Exam #2

III. Microbes in the Environment

25. Microbial Ecosystems – Chpt 23
26. Bioremediation – Chpt 24
27. Industrial Microbiology – Chpt 25 and 26
28. Growth Control – Chpt 27
29. Interactions with Humans – Chpt 28
30. Microbial Diseases – Chpt 34
31. Microbial Diseases – Chpt 35
32. Water quality and microbes – Chpt 36
33. Food Preservation – Chpt 37
34. Review session
35. Exam #3

IV. The Immune System

36. The immune system overview – chpt 29
37. The immune system - Chpt 29
38. Innate Immunity – antimicrobial peptides and complement system – Chpt 30
39. Innate Immunity – Toll receptors – Chpt 30
40. Acquired Immunity – B and T cell populations – Chpt 31
41. Acquired Immunity – mounting an immune response – Chpt 31
42. Acquired Immunity – immunological memory – Chpt 31
43. Disease Diagnosis – Chpt 32
44. Epidemiology – Chpt 33
45. Review session
46. Exam #4

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