BIO302: Introduction to Molecular Biology
(Fall, 2009) Tue/Thurs, 11:00 am - 12:20 pm, 114 Hochstetter Hall
Instructors:
Dr. Jeremy Bruenn 661 Cooke Hall, ph. 645-2363x176 Office hours: Tues/Thurs: 12:30 to 1:30 PM Email: cambruen@nsm.buffalo.edu
Dr. Randall D. Shortridge 336 Cooke Hall, ph. 645-2363x137 Office hours: Tues/Thurs: 12:30 to 1:30 PM Email: rds@buffalo.edu
Course Description:
An introduction to molecular biology with an emphasis on its use in biotechnology. Students taking this course should have an understanding of the fundamentals of cell biology and the basics of biochemistry. Prerequisite: BIO 205 or equivalent course.
Text (required):
Recombinant DNA, Genes and Genomes - A Short Course (3rd Edition) James D. Watson, Jan Witkowski, Richard M. Myers, and Amy A. Caudy W.H. Freeman and Company
Exams:
There will be 3 exams, each of which will be 1/3 of the final grade. The last exam will not be cumulative. Make-up exams will be given only with a valid medical excuse and will be oral or written at the instructor's option. If you have a medical reason for missing an exam, the instructor must be notified within 24 hours of missing the exam. If notification is not given, you will receive a grade of zero for that exam. The following is an approximate schedule of lectures. Exam dates will not change.
Grading:
Grades will be assigned based on the percentage of total points (ie, above 90% will get A's, 80% to 90% will get B's, and so on) or, alternatively, on a curve basis if the class average falls significantly below 75%.
Other information pertinent to this class will be posted at UB Learns.
Class |
Date |
Topics |
Instructor (Textbook Chapter) |
| 1 | 9/1 | Introduction | Bruenn (Chapter 1) |
| 2 | 9/3 | Information Flow from DNA to Protein | Bruenn (Chapter 2) |
| 3 | 9/8 | Information Flow from DNA to Protein | Bruenn (Chapter 2) |
| 4 | 9/10 | Control of Gene Expression | Bruenn (Chapter 3) |
| 5 | 9/15 | Basic Tools of Recombinant DNA | Bruenn (Chapter 4) |
| 6 | 9/17 | Basic Tools of Recombinant DNA | Bruenn (Chapter 4) |
| 7 | 9/22 | Fundamental Features of Eukaryotic Genes | Bruenn (Chapter 5) |
| 8 | 9/24 | A New Toolbox for Recombinant DNA | Bruenn (Chapter 6) |
| 9/29 | Exam 1 (Lecture # 1-8) |
||
| 9 | 10/1 | Mobile DNA Sequences in the Genome | Shortridge (Chapter 7) |
| 10 | 10/6 | Mobile DNA Sequences in the Genome | Shortridge (Chapter 7) |
| 11 | 10/8 | Epigenetic Modifications of the Genome | Shortridge (Chapter 8) |
| 12 | 10/13 | Epigenetic Modifications of the Genome | Shortridge (Chapter 8) |
| 13 | 10/15 | RNA Interference Regulates Gene Action | Shortridge (Chapter 9) |
| 14 | 10/20 | RNA Interference Regulates Gene Action | Shortridge (Chapter 9) |
| 15 | 10/22 | Fundamentals of Whole Genome Sequencing | Shortridge (Chapter 10) |
| 16 | 10/27 | Fundamentals of Whole Genome Sequencing | Shortridge (Chapter 10) |
| 17 | 10/29 | Comparing and Analyzing Genome | Bruenn (Chapter 12) |
| 11/3 | Exam 2 (Lecture # 9-16) |
||
| 18 | 11/5 | From Genome Sequence to Gene Function | Bruenn (Chapter 13) |
| 19 | 11/10 | From Genome Sequence to Gene Function | Bruenn (Chapter 13) |
| 20 | 11/12 | Finding Human Disease Genes | Bruenn (Chapter 14) |
| 21 | 11/17 | Finding Human Disease Genes | Bruenn (Chapter 14) |
| 22 | 11/19 | Understanding the Genetic Basis of Cancer | Bruenn (Chapter 15) |
| 23 | 11/24 | Understanding the Genetic Basis of Cancer | Bruenn (Chapter 15) |
| 11/26 | No Class - Thanksgiving Holiday | ||
| 24 | 12/1 | DNA Fingerprinting and Forensics | Bruenn (Chapter 16) |
| 26 | 12/3 | DNA Fingerprinting and Forensics | Bruenn (Chapter 16) |
| 26 | 12/8 | Review |
|
| 12/10 | Exam 3 (Lecture # 17 - 25) 11:00 AM- 12:20 PM in H114 |