BIO302: Introduction to Molecular Biology
(Fall, 2010) Tue/Thurs, 11:00 am - 12:20 pm, 121 CookeHall
Instructors:
Dr. Jeremy Bruenn
661 Cooke Hall, ph. 645-4967
Office hours: Tues/Thurs: 12:30 to 1:30 PM
Email: cambruen@nsm.buffalo.eduDr. Randall D. Shortridge
336 Cooke Hall, ph. 645-4920
Office hours: Tues/Thurs: 12:30 to 1:30 PM
Email: rds@buffalo.edu
Course Description:
An introduction to molecular biology with an emphasis on its use in biotechnology. Students taking this course should have an understanding of the fundamentals of cell biology and the basics of biochemistry. Prerequisite: BIO 205 or equivalent course.
Text (required):
Recombinant DNA, Genes and Genomes - A Short Course (3rd Edition)
James D. Watson, Jan Witkowski, Richard M. Myers, and Amy A. Caudy
W.H. Freeman and Company
Clickers (required):
Turning Technologies response cards (clickers) will be available in the bookstore and are required. Students are responsible for registering their clickers and tuning them to the proper frequency (channel 21). See the Ubclicks website at http://etc.buffalo.edu/clickers/StudentClickerTutorial.pdf
Exams:
There will be 2 exams, each of which will be 1/3 of the final grade. The last exam will not be cumulative. Make-up exams will be given only with a valid medical excuse and will be oral or written at the instructor's option. If you have a medical reason for missing an exam, the instructor must be notified within 24 hours of missing the exam. If notification is not given, you will receive a grade of zero for that exam. The remaining third of the grade will be assigned from clicker responses during lectures. The following is an approximate schedule of lectures. Exam dates will not change.
Grading:
Grades will be assigned based on the percentage of total points (ie, above 90% will get A's, 80% to 90% will get B's, and so on) or, alternatively, on a curve basis if the class average falls significantly below 75%.
Other information pertinent to this class will be posted at UB Learns.
Class |
Date |
Topics |
Instructor (Textbook Chapter) |
| 1 | 8/31 | Introduction to Molecular Biology (MB) | Shortridge (Chapter 1 and 2) |
| 2 | 9/2 | Information Flow and Gene Expression | Shortridge (Chapter 2 and 3) |
| 3 | 9/7 | Gene Expression and MB Tools | Shortridge (Chapter 3 and 4) |
| 3 | 9/9 | Holiday - No Class | |
| 4 | 9/14 | Tools of MB | Shortridge (Chapter 4) |
| 5 | 9/16 | Eukaryotic Genes | Shortridge (Chapter 5) |
| 6 | 9/21 | Features of Genes and Newest MB Tools | Shortridge (Chapter 5 and 6) |
| 7 | 9/23 | Newest MB Tools | Shortridge (Chapter 6) |
| 8 | 9/28 | Mobile DNA Sequences | Shortridge (Chapter 7) |
| 9 | 9/30 | Mobile DNA Sequences | Shortridge (Chapter 7) |
| 10 | 10/5 | Epigenetics | Shortridge (Chapter 8) |
| 11 | 10/7 | Epigenetics | Shortridge (Chapter 8) |
| 12 | 10/12 | Biocentrism and related models | Shortridge (special topic) |
| 10/14 | Exam 1 (Lectures 1-13) | Shortridge | |
| 13 | 10/19 | RNA Interference Regulates Gene Action | Bruenn (Chapter 9) |
| 14 | 10/21 | Fundamentals of Whole Genome Sequencing | Bruenn (Chapter 10) |
| 15 | 10/26 | How the Human Genome Was Sequenced | Bruenn (Chapter 11) |
| 16 | 10/28 | Comparing and Analyzing Genome | Bruenn (Chapter 12) |
| 17 | 11/2 | Comparing and Analyzing Genome | Bruenn (Chapter 12) |
| 18 | 11/4 | From Genome Sequence to Gene Function | Bruenn (Chapter 13) |
| 19 | 11/9 | From Genome Sequence to Gene Function | Bruenn (Chapter 13) |
| 20 | 11/11 | Finding Human Disease Genes | Bruenn (Chapter 14) |
| 21 | 11/16 | Finding Human Disease Genes | Bruenn (Chapter 14) |
| 22 | 11/18 | Understanding the Genetic Basis of Cancer | Bruenn (Chapter 15) |
| 23 | 11/23 | Understanding the Genetic Basis of Cancer | Bruenn (Chapter 15) |
| 11/25 | No Class - Thanksgiving Holiday | ||
| 24 | 11/30 | DNA Fingerprinting and Forensics | Bruenn (Chapter 16) |
| 25 | 12/2 | DNA Fingerprinting and Forensics | Bruenn (Chapter 16) |
| 26 | 12/7 | Review | Bruenn |
| 12/10 | Exam 2 (Lectures 14 - 26) | Bruenn |