BIO302: Introduction to Molecular Biology
(Fall, 2009) Tue/Thurs, 11:00 am - 12:20 pm, 114 Hochstetter Hall

Instructors:

Dr. Jeremy Bruenn 661 Cooke Hall, ph. 645-2363x176 Office hours: Tues/Thurs: 12:30 to 1:30 PM Email: cambruen@nsm.buffalo.edu

Dr. Randall D. Shortridge 336 Cooke Hall, ph. 645-2363x137 Office hours: Tues/Thurs: 12:30 to 1:30 PM Email: rds@buffalo.edu

Course Description:

An introduction to molecular biology with an emphasis on its use in biotechnology. Students taking this course should have an understanding of the fundamentals of cell biology and the basics of biochemistry. Prerequisite: BIO 205 or equivalent course.

Text (required):

Recombinant DNA, Genes and Genomes - A Short Course (3rd Edition) James D. Watson, Jan Witkowski, Richard M. Myers, and Amy A. Caudy W.H. Freeman and Company

Exams:

There will be 3 exams, each of which will be 1/3 of the final grade. The last exam will not be cumulative. Make-up exams will be given only with a valid medical excuse and will be oral or written at the instructor's option. If you have a medical reason for missing an exam, the instructor must be notified within 24 hours of missing the exam. If notification is not given, you will receive a grade of zero for that exam. The following is an approximate schedule of lectures. Exam dates will not change.

Grading:

Grades will be assigned based on the percentage of total points (ie, above 90% will get A's, 80% to 90% will get B's, and so on) or, alternatively, on a curve basis if the class average falls significantly below 75%.

Other information pertinent to this class will be posted at UB Learns.

Class
Date
Topics
Instructor
(Textbook Chapter)
1 9/1 Introduction Bruenn (Chapter 1)
2 9/3 Information Flow from DNA to Protein Bruenn (Chapter 2)
3 9/8 Information Flow from DNA to Protein Bruenn (Chapter 2)
4 9/10 Control of Gene Expression Bruenn (Chapter 3)
5 9/15 Basic Tools of Recombinant DNA Bruenn (Chapter 4)
6 9/17 Basic Tools of Recombinant DNA Bruenn (Chapter 4)
7 9/22 Fundamental Features of Eukaryotic Genes Bruenn (Chapter 5)
8 9/24 A New Toolbox for Recombinant DNA Bruenn (Chapter 6)
9/29
Exam 1 (Lecture # 1-8)
9 10/1 Mobile DNA Sequences in the Genome Shortridge (Chapter 7)
10 10/6 Mobile DNA Sequences in the Genome Shortridge (Chapter 7)
11 10/8 Epigenetic Modifications of the Genome Shortridge (Chapter 8)
12 10/13 Epigenetic Modifications of the Genome Shortridge (Chapter 8)
13 10/15 RNA Interference Regulates Gene Action Shortridge (Chapter 9)
14 10/20 RNA Interference Regulates Gene Action Shortridge (Chapter 9)
15 10/22 Fundamentals of Whole Genome Sequencing Shortridge (Chapter 10)
16 10/27 Fundamentals of Whole Genome Sequencing Shortridge (Chapter 10)
17 10/29 Comparing and Analyzing Genome Bruenn (Chapter 12)
11/3
Exam 2 (Lecture # 9-16)
18 11/5 From Genome Sequence to Gene Function Bruenn (Chapter 13)
19 11/10 From Genome Sequence to Gene Function Bruenn (Chapter 13)
20 11/12 Finding Human Disease Genes Bruenn (Chapter 14)
21 11/17 Finding Human Disease Genes Bruenn (Chapter 14)
22 11/19 Understanding the Genetic Basis of Cancer Bruenn (Chapter 15)
23 11/24 Understanding the Genetic Basis of Cancer Bruenn (Chapter 15)
11/26 No Class - Thanksgiving Holiday
24 12/1 DNA Fingerprinting and Forensics Bruenn (Chapter 16)
26 12/3 DNA Fingerprinting and Forensics Bruenn (Chapter 16)
26 12/8
Review
12/10
Exam 3 (Lecture # 17 - 25)
11:00 AM- 12:20 PM in H114