BIO302: Introduction to Molecular Biology
(Fall, 2010) Tue/Thurs, 11:00 am - 12:20 pm, 121 CookeHall

Instructors:

Dr. Jeremy Bruenn
661 Cooke Hall, ph. 645-4967
Office hours: Tues/Thurs: 12:30 to 1:30 PM
Email: cambruen@nsm.buffalo.edu

Dr. Randall D. Shortridge
336 Cooke Hall, ph. 645-4920
Office hours: Tues/Thurs: 12:30 to 1:30 PM
Email: rds@buffalo.edu

Course Description:

An introduction to molecular biology with an emphasis on its use in biotechnology. Students taking this course should have an understanding of the fundamentals of cell biology and the basics of biochemistry. Prerequisite: BIO 205 or equivalent course.

Text (required):

Recombinant DNA, Genes and Genomes - A Short Course (3rd Edition)
James D. Watson, Jan Witkowski, Richard M. Myers, and Amy A. Caudy
W.H. Freeman and Company

Clickers (required):

Turning Technologies response cards (clickers) will be available in the bookstore and are required. Students are responsible for registering their clickers and tuning them to the proper frequency (channel 21). See the Ubclicks website at http://etc.buffalo.edu/clickers/StudentClickerTutorial.pdf

Exams:

There will be 2 exams, each of which will be 1/3 of the final grade. The last exam will not be cumulative. Make-up exams will be given only with a valid medical excuse and will be oral or written at the instructor's option. If you have a medical reason for missing an exam, the instructor must be notified within 24 hours of missing the exam. If notification is not given, you will receive a grade of zero for that exam. The remaining third of the grade will be assigned from clicker responses during lectures. The following is an approximate schedule of lectures. Exam dates will not change.

Grading:

Grades will be assigned based on the percentage of total points (ie, above 90% will get A's, 80% to 90% will get B's, and so on) or, alternatively, on a curve basis if the class average falls significantly below 75%.

Other information pertinent to this class will be posted at UB Learns.

Class
Date
Topics
Instructor
(Textbook Chapter)
1 8/31 Introduction to Molecular Biology (MB) Shortridge (Chapter 1 and 2)
2 9/2 Information Flow and Gene Expression Shortridge (Chapter 2 and 3)
3 9/7 Gene Expression and MB Tools Shortridge (Chapter 3 and 4)
3 9/9 Holiday - No Class  
4 9/14 Tools of MB Shortridge (Chapter 4)
5 9/16 Eukaryotic Genes Shortridge (Chapter 5)
6 9/21 Features of Genes and Newest MB Tools Shortridge (Chapter 5 and 6)
7 9/23 Newest MB Tools Shortridge (Chapter 6)
8 9/28 Mobile DNA Sequences Shortridge (Chapter 7)
9 9/30 Mobile DNA Sequences Shortridge (Chapter 7)
10 10/5 Epigenetics Shortridge (Chapter 8)
11 10/7 Epigenetics Shortridge (Chapter 8)
12 10/12 Biocentrism and related models Shortridge (special topic)
  10/14 Exam 1 (Lectures 1-13) Shortridge
13 10/19 RNA Interference Regulates Gene Action Bruenn (Chapter 9)
14 10/21 Fundamentals of Whole Genome Sequencing Bruenn (Chapter 10)
15 10/26 How the Human Genome Was Sequenced Bruenn (Chapter 11)
16 10/28 Comparing and Analyzing Genome Bruenn (Chapter 12)
17 11/2 Comparing and Analyzing Genome Bruenn (Chapter 12)
18 11/4 From Genome Sequence to Gene Function Bruenn (Chapter 13)
19 11/9 From Genome Sequence to Gene Function Bruenn (Chapter 13)
20 11/11 Finding Human Disease Genes Bruenn (Chapter 14)
21 11/16 Finding Human Disease Genes Bruenn (Chapter 14)
22 11/18 Understanding the Genetic Basis of Cancer Bruenn (Chapter 15)
23 11/23 Understanding the Genetic Basis of Cancer Bruenn (Chapter 15)
11/25 No Class - Thanksgiving Holiday
24 11/30 DNA Fingerprinting and Forensics Bruenn (Chapter 16)
25 12/2 DNA Fingerprinting and Forensics Bruenn (Chapter 16)
26 12/7 Review Bruenn
12/10 Exam 2 (Lectures 14 - 26) Bruenn